Pharmaceutical · Fiscal year end Dec 31

Otsuka Holdings Co., Ltd.

4578

大塚ホールディングス株式会社

FIGI BBG000DZLC984578.T4578 JPCorp. no. 4010001118786

Latest half-year results

First half · fiscal year to 2026-12 · filed 2026-07-31

For the first half of the fiscal year to 2026-12: Revenue ¥1.33 trillion (+12.8% YoY), Profit before tax ¥285.4 billion (+26.1% YoY), Net income ¥215.6 billion (+24.3% YoY).

	This period	Year on year
Revenue	¥1.3tn	+12.8%
Profit before tax	¥285.4bn	+26.1%
Net profit to owners	¥215.6bn	+24.3%

From the securities report on EDINET, which states no forecast. History via /v1/companies/4578/earnings-releases.

Financials

IFRS · consolidated · fiscal year to 2025-12-31

Revenue: ¥2.5tn
Net income: ¥363.2bn
ROE: 12.6%
Equity ratio: 72.3%
Dividend / share: ¥140
Employees: 37,758

Revenue · ¥tn

Net income · ¥bn

Fiscal year	Revenue	Net income	Total assets	Net assets	ROE	EPS	Operating CF
2025-12-31	¥2,468.9bn	¥363.2bn	¥4,197.6bn	¥3,033.4bn	12.6%	¥685.06	¥403.6bn
2024-12-31	¥2,329.9bn	¥343.1bn	¥3,739.3bn	¥2,733.6bn	13.4%	¥633.76	¥354.6bn
2023-12-31	¥2,018.6bn	¥121.6bn	¥3,361.2bn	¥2,393.7bn	5.3%	¥224.1	¥283.2bn
2022-12-31	¥1,738.0bn	¥133.9bn	¥3,102.6bn	¥2,225.3bn	6.3%	¥246.8	¥211.8bn
2021-12-31	¥1,498.3bn	¥125.5bn	¥2,820.9bn	¥2,011.0bn	6.5%	¥231.32	¥228.9bn

Indicators

Computed by us from filings · fiscal year to 2025-12-31

Metric	Value	Percentile among listed companies
ROE, %	12.6	70.1
Ordinary margin	0.1896	89
Equity ratio, %	72.3	78.6
Revenue growth	0.0597	54.9
Net income growth	0.0584	41.7
Operating cash flow / assets	0.0961	70.8

Policy-uncertainty measure1.02 Share of the report's text discussing policy-related uncertainty, by policy area. Proprietary text method.

Trade & tariffs 1 Regulation 3 Politics & geopolitics 2

Ownership activity 0 filer(s) stated they may make proposals in 365 days; 0 new 5% holder(s) in 180 days; net stake change 0.00pt in 90 days; 6.8% held by other listed companies.

Results wording balance: +0.85. Proprietary text method; it describes the wording only and does not interpret context.

Interest example: if all ¥127.0bn of reported debt repriced by 50 basis points, a year's interest would rise by ¥635m, 0.2% of operating cash flow. Our arithmetic only, not a forecast: fixed-rate debt and hedges are ignored.

Via /v1/companies/4578/indicators. Descriptive figures, not a rating and not investment advice.

From other filings

As the company states them

Share buyback, report to —: ¥47.0bn acquired of a ¥50.0bn limit. /v1/companies/4578/buybacks

Internal control, 2026-03-26: see filing 上記の評価手続を実施した結果、2025年12月31日現在の当社の財務報告に係る内部統制は有効であると判断しました。 Filing

Segments, votes and tender offers

Stated in EDINET filings

Segments: Pharmaceuticals, Nutraceuticals, Consumer Products, Other. /v1/companies/4578/segments

Latest voting result: 2026-03-27 · 取締役13名選任の件 · passed. /v1/companies/4578/voting

Ownership changes

All companies →

2026-03-05

New 5% stake

Nomura Securities Co.,Ltd. disclosed a 5.03% stake in Otsuka Holdings Co., Ltd. (4578), crossing the 5% reporting threshold.

S100XOM4Filer profile Original filing (PDF, Japanese)
2025-12-02

Below 5%−0.40pt

Nomura Securities Co.,Ltd. cut holdings in Otsuka Holdings Co., Ltd. (4578) to 4.82% from 5.22%, below the 5% threshold.

S100X836Filer profile Original filing (PDF, Japanese)
2025-10-07

Increase+0.20pt

Nomura Securities Co.,Ltd. raised holdings in Otsuka Holdings Co., Ltd. (4578) to 5.22% from 5.02%.

S100WTMSFiler profile Original filing (PDF, Japanese)
2025-09-19

Below 5%−0.48pt

Sumitomo Mitsui Trust Asset Management Co.,Ltd. cut holdings in Otsuka Holdings Co., Ltd. (4578) to 4.56% from 5.04%, below the 5% threshold.

S100WPCGFiler profile Original filing (PDF, Japanese)
2025-06-19

New 5% stake

Sumitomo Mitsui Trust Asset Management Co.,Ltd. disclosed a 5.04% stake in Otsuka Holdings Co., Ltd. (4578), crossing the 5% reporting threshold.

S100VYDSFiler profile Original filing (PDF, Japanese)
2024-09-20

New 5% stake

Nomura Securities Co.,Ltd. disclosed a 5.02% stake in Otsuka Holdings Co., Ltd. (4578), crossing the 5% reporting threshold.

S100UE9OFiler profile Original filing (PDF, Japanese)
2023-04-05

Increase+1.04pt

BlackRock Japan Co., Ltd. raised holdings in Otsuka Holdings Co., Ltd. (4578) to 6.08% from 5.04%.

S100QJLRFiler profile Original filing (PDF, Japanese)
2022-06-06

New 5% stake

BlackRock Japan Co., Ltd. disclosed a 5.04% stake in Otsuka Holdings Co., Ltd. (4578), crossing the 5% reporting threshold.

S100O6XRFiler profile Original filing (PDF, Japanese)
2022-03-23

Decrease−1.14pt

individual filer reduced holdings in Otsuka Holdings Co., Ltd. (4578) to 10.34% from 11.48%.

S100NODBOriginal filing (PDF, Japanese)

Trades by 5% holders

From the 60-day trade tables in 5% reports

Holder	Period	Net shares	Net % of shares	Avg. filed price	Range
individual filer	2021-12-20 – 2021-12-20	-1,198,601	−0.21pt	¥90	¥90–90

Net shares and the average are our calculations. Prices are filed prices as stated by the filer, mostly for off-market trades; they are not market prices. Stock lending, custody transfers and option exercises are excluded from net shares. Every row via /v1/companies/4578/trades.

5% filings

Large shareholding reports on 4578

Filed	Filer	Stake	Change	Stated purpose
2026-03-05	Nomura Securities Co.,Ltd.	5.03%	—	—
2025-12-02	Nomura Securities Co.,Ltd.	4.82%	−0.40pt	—
2025-10-07	Nomura Securities Co.,Ltd.	5.22%	+0.20pt	—
2025-09-19	Sumitomo Mitsui Trust Asset Management Co.,Ltd.	4.56%	−0.48pt	—
2025-06-19	Sumitomo Mitsui Trust Asset Management Co.,Ltd.	5.04%	—	—
2024-09-20	Nomura Securities Co.,Ltd.	5.02%	—	—
2023-04-05	BlackRock Japan Co., Ltd.	6.08%	+1.04pt	pure investment
2022-06-06	BlackRock Japan Co., Ltd.	5.04%	—	pure investment
2022-03-23	individual filer	10.34%	−1.14pt	—

Cross-shareholdings

From the annual report's status of shareholdings

Listed strategic holdings: 3 issues
Book value: ¥5.8bn
Sold in the year: — — issues
Bought in the year: — — issues
Mutual, both reports: 13
Held by listed cos.: 24

Holds	Book value	Shares vs. prior year	Mutual
DAIICHI SANKYO COMPANY, LIMITED 4568	¥21.4bn	0.0%	no
The Awa Bank,Ltd. 8388	¥4.1bn	0.0%	both reports
TOHO HOLDINGS CO.,LTD. 8129	¥3.7bn	0.0%	both reports
MEDIPAL HOLDINGS CORPORATION 7459	¥3.2bn	0.0%	both reports
Dong-A Socio Holdings Co., Ltd.	¥3.1bn	+3.0%	no
Dong-A ST Co., Ltd.	¥2.6bn	+2.0%	no
ONO PHARMACEUTICAL CO., LTD. 4528	¥2.6bn	0.0%	both reports
Arcus Biosciences, Inc.	¥2.2bn	0.0%	no
MEGMILK SNOW BRAND Co.,Ltd. 2270	¥2.0bn	0.0%	both reports
Shochiku Co;Ltd. 9601	¥1.7bn	0.0%	both reports

Held by: The Awa Bank,Ltd. 8388, Resona Holdings, Inc. 8308, MEDIPAL HOLDINGS CORPORATION 7459, SUZUKEN CO.,LTD. 9987, VITAL KSK HOLDINGS,INC. 3151, TOHO HOLDINGS CO.,LTD. 8129, VITAL KSK HOLDINGS,INC. 3151, Alfresa Holdings Corporation 2784, MEGMILK SNOW BRAND Co.,Ltd. 2270, Toyo Seikan Group Holdings, Ltd. 5901, Alfresa Holdings Corporation 2784, OHKI HEALTHCARE HOLDINGS CO.,LTD. 3417 and 15 more

Purposes, all holdings and mutual flags via /v1/companies/4578/cross-holdings. Share changes include stock splits.

Major shareholders

As of fiscal year end 2025-12-31

Shareholder	Shares	Ratio
日本マスタートラスト信託銀行㈱（信託口）	77,620,000	14.69%
野村信託銀行㈱　大塚創業家持株会信託口	52,353,000	9.91%
㈱日本カストディ銀行（信託口）	29,804,000	5.64%
STATE STREET BANK AND TRUST COMPANY 505001	15,756,000	2.98%
大塚グループ従業員持株会	12,568,000	2.37%
㈱阿波銀行	10,970,000	2.07%
JP MORGAN CHASE BANK 385781	7,839,000	1.48%
㈱りそな銀行	5,568,000	1.05%
㈱メディパルホールディングス	5,316,000	1.00%
日亜化学工業㈱	4,793,000	0.90%

U.S. funds holding 4578

SEC Form N-PORT, reports to 2026-07-31

294 U.S. funds held 47,750,926 shares worth $3.31bn.

Fund	Shares	Value	% of fund	As of
VANGUARD TOTAL INTERNATIONAL STOCK INDEX FUND VANGUARD STAR FUNDS	6,522,505	$452.3m	0.070%	2026-07-31
VANGUARD HEALTH CARE FUND VANGUARD SPECIALIZED FUNDS	5,423,000	$376.0m	0.985%	2026-07-31
VANGUARD DEVELOPED MARKETS INDEX FUND VANGUARD TAX-MANAGED FUNDS	4,328,901	$288.1m	0.091%	2026-06-30
iShares Core MSCI EAFE ETF iShares Trust	3,123,700	$216.6m	0.114%	2026-07-31
iShares MSCI Japan ETF iShares, Inc.	1,771,400	$130.1m	0.611%	2026-05-31

Up to 25 funds per stock via the API.

Get this as JSON

GET /v1/companies/4578
GET /v1/companies/4578/financials
GET /v1/companies/4578/details
GET /v1/companies/4578/segments
GET /v1/companies/4578/voting
GET /v1/companies/4578/tender-offers
GET /v1/companies/4578/indicators
GET /v1/companies/4578/earnings-releases
GET /v1/events?ticker=4578
GET /v1/companies/4578/trades         
GET /v1/companies/4578/cross-holdings 
GET /v1/companies/4578/brief

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